Studies on peptides. CXX. Synthesis of growth hormone releasing factor (GRF-37-NH2) and N.ALPHA.-biotinyl-GRF-44-NH2.
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چکیده
منابع مشابه
Effect of growth hormone-releasing factor (1-29)NH2 and thyrotropin-releasing factor on growth hormone release in lactating sows.
Résumé. Vingt-six truies en lactation ont reçu les traitements suivants : 1) solution saline physiologique ; 2) somatocrinine ou hGRF(1-29)NH 2(20 ¡lg.kg1) ; 3) thyréolibérine (TRF) (1 ¡lg.kg) ; 4) combinaison de GRF et de TRF (20 et 1 ¡lg.kgrespectivement). La solution saline ou les peptides ont été injectés par voie sous-cutanée, deux fois par jour, du 5e au 25e jour post-partum. Les niveaux ...
متن کاملDose response of two synthetic human growth hormone-releasing factors on growth hormone release in heifers and pigs.
This study was undertaken to evaluate the biological potency of two synthetic human growth hormone-releasing factors, hGRF (1-44)NH2 and hGRF (1-29)NH2, on growth hormone (GH) release in young dairy heifers (n = 10) and pigs (n = 10). In each species, the GH response to an iv injection (0, .067, .2, .6 and 1.8 nmol.kg-1 body weight) of each peptide was evaluated in a double 5 X 5 Latin square d...
متن کاملAbnormalities of growth hormone release in response to human pancreatic growth hormone releasing factor (GRF (1-44) ) in acromegaly and hypopituitarism.
Human pancreatic growth hormone releasing factor (GRF (1-44)) is the parent molecule of several peptides recently extracted from pancreatic tumours associated with acromegaly. A study was conducted to examine its effects on the release of growth hormone in normal volunteers and in patients with hypopituitarism and acromegaly. GRF (1-44) dose dependently stimulated the release of growth hormone ...
متن کاملCharacteristics of growth hormone response to the administration of growth hormone-releasing hormone (GRF) in the lamb.
Human growth hormone releasing hormone (GRF 1-44 or GRF 1-29) was administered to lambs at two different physiological stages (suckling: 5-6 week-old and weaned: 14-15 week-old) when growth hormone (GH) secretory patterns were different: suckling lambs exhibited flat basal GH profiles (5-10 ng/ml) while the weaned lambs had frequent spontaneous episodes of GH release (15-65 ng/ml). The iv injec...
متن کاملGrowth hormone responses to hp GRF 1-44 amide, bromocriptine and stress in acromegaly are correlated.
The results of testing growth hormone (GH) reserve using human pancreatic growth hormone-releasing factor 1-44 amide (hp GRF 1-44 amide) have been compared with the GH responses in a variety of other dynamic tests in seven acromegalic patients. The GH release following hp GRF 1-44 amide correlated with the GH suppression following bromocriptine, but showed an inverse correlation with the GH rel...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1984
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.32.1200